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Hippocampal development and neural stem cell maintenance require Sox2-dependent regulation of Shh

This was predicted to stabilise the N-terminal -helix (5-18) of the peptide through formation of an intramolecular salt bridge, as observed in a crystal structure of CagriBB fused at the C-terminal end of maltose-binding protein (PDB:7BG0) 2

Later research used fixed microgram amounts subcutaneously

Although these drugs are effective in improving cognitive function and daily living abilities, they have limited efficacy in diabetic cognitive dysfunction, and available data suggest that antidiabetic drugs have the potential to improve cognitive dysfunction and dementia (9)

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Most studies are conducted under controlled conditions, which may not reflect real-life outcomes